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Synthesis and Evaluation of a Series of New Bulleyaconitine A Derivatives as Analgesics
[Image: see text] As a nonaddictive analgesic widely used in clinics, the LD(50) of bulleyaconitine A is just only 0.92 mg/kg, which exhibits obvious toxicity. Therefore, 31 new non-natural C(19)-diterpenoid alkaloids (2a–w, 2′a–e, 3, 4a, and 4b) were designed and synthesized from bulleyaconitine A...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450621/ https://www.ncbi.nlm.nih.gov/pubmed/32875257 http://dx.doi.org/10.1021/acsomega.0c02944 |