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Synthesis and Evaluation of a Series of New Bulleyaconitine A Derivatives as Analgesics

[Image: see text] As a nonaddictive analgesic widely used in clinics, the LD(50) of bulleyaconitine A is just only 0.92 mg/kg, which exhibits obvious toxicity. Therefore, 31 new non-natural C(19)-diterpenoid alkaloids (2a–w, 2′a–e, 3, 4a, and 4b) were designed and synthesized from bulleyaconitine A...

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Detalles Bibliográficos
Autores principales:	Zhang, Xing, Shang, Yu-Shan, Gao, Feng, Fang, Dong-Mei, Li, Xiao-Huan, Zhou, Xian-Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450621/ https://www.ncbi.nlm.nih.gov/pubmed/32875257 http://dx.doi.org/10.1021/acsomega.0c02944

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