Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy

[Image: see text] NMR spectroscopy is a powerful technique for separating and measuring each distinct pK(a) value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments were made for each individual amine substituent on 2-deoxystreptamine, tobramycin, kanamycin B, amikacin, s...

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Detalles Bibliográficos
Autores principales: Alkhzem, Abdulaziz H., Woodman, Timothy J., Blagbrough, Ian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450637/
https://www.ncbi.nlm.nih.gov/pubmed/32875246
http://dx.doi.org/10.1021/acsomega.0c02744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450637/
https://www.ncbi.nlm.nih.gov/pubmed/32875246
http://dx.doi.org/10.1021/acsomega.0c02744

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