Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy

[Image: see text] NMR spectroscopy is a powerful technique for separating and measuring each distinct pK(a) value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments were made for each individual amine substituent on 2-deoxystreptamine, tobramycin, kanamycin B, amikacin, s...

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Autores principales: Alkhzem, Abdulaziz H., Woodman, Timothy J., Blagbrough, Ian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450637/
https://www.ncbi.nlm.nih.gov/pubmed/32875246
http://dx.doi.org/10.1021/acsomega.0c02744
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author Alkhzem, Abdulaziz H.
Woodman, Timothy J.
Blagbrough, Ian S.
author_facet Alkhzem, Abdulaziz H.
Woodman, Timothy J.
Blagbrough, Ian S.
author_sort Alkhzem, Abdulaziz H.
collection PubMed
description [Image: see text] NMR spectroscopy is a powerful technique for separating and measuring each distinct pK(a) value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments were made for each individual amine substituent on 2-deoxystreptamine, tobramycin, kanamycin B, amikacin, sisomicin, and netilmicin using variations in the NMR spectroscopic chemical shift (δ) with (1)H, (13)C, and (15)N HMBC; the individual pK(a) values of netilmicin are reported for the first time.
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spelling pubmed-74506372020-08-31 Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy Alkhzem, Abdulaziz H. Woodman, Timothy J. Blagbrough, Ian S. ACS Omega [Image: see text] NMR spectroscopy is a powerful technique for separating and measuring each distinct pK(a) value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments were made for each individual amine substituent on 2-deoxystreptamine, tobramycin, kanamycin B, amikacin, sisomicin, and netilmicin using variations in the NMR spectroscopic chemical shift (δ) with (1)H, (13)C, and (15)N HMBC; the individual pK(a) values of netilmicin are reported for the first time. American Chemical Society 2020-08-11 /pmc/articles/PMC7450637/ /pubmed/32875246 http://dx.doi.org/10.1021/acsomega.0c02744 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Alkhzem, Abdulaziz H.
Woodman, Timothy J.
Blagbrough, Ian S.
Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy
title Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy
title_full Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy
title_fullStr Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy
title_full_unstemmed Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy
title_short Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy
title_sort individual pk(a) values of tobramycin, kanamycin b, amikacin, sisomicin, and netilmicin determined by multinuclear nmr spectroscopy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450637/
https://www.ncbi.nlm.nih.gov/pubmed/32875246
http://dx.doi.org/10.1021/acsomega.0c02744
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