Synthesis of a (11)C-Isotopologue of the B-Raf-Selective Inhibitor Encorafenib Using In-Loop [(11)C]CO(2) Fixation

[Image: see text] The serine/threonine kinase B-Raf is an essential regulator of cellular growth, differentiation, and survival. B-Raf protein expression is elevated throughout melanoma progression, making it an attractive target for noninvasive imaging using positron–emission tomography. Encorafeni...

Descripción completa

Detalles Bibliográficos
Autores principales: Dornan, Mark H., Petrenyov, Daniil, Simard, José-Mathieu, Boudjemeline, Mehdi, Mititelu, Roxana, DaSilva, Jean N., Belanger, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450646/
https://www.ncbi.nlm.nih.gov/pubmed/32875231
http://dx.doi.org/10.1021/acsomega.0c02419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450646/
https://www.ncbi.nlm.nih.gov/pubmed/32875231
http://dx.doi.org/10.1021/acsomega.0c02419

Ejemplares similares