Cargando…
Conformational selection of allergen-antibody complexes—surface plasticity of paratopes and epitopes
Antibodies have the ability to bind various types of antigens and to recognize different antibody-binding sites (epitopes) of the same antigen with different binding affinities. Due to the conserved structural framework of antibodies, their specificity to antigens is mainly determined by their antig...
Autores principales: | Fernández-Quintero, Monica L, Loeffler, Johannes R, Waibl, Franz, Kamenik, Anna S, Hofer, Florian, Liedl, Klaus R |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451023/ https://www.ncbi.nlm.nih.gov/pubmed/32719844 http://dx.doi.org/10.1093/protein/gzaa014 |
Ejemplares similares
-
Conformational Ensembles of Antibodies Determine Their Hydrophobicity
por: Waibl, Franz, et al.
Publicado: (2021) -
pH-dependent structural diversity of profilin allergens determines thermal stability
por: Hofer, Florian, et al.
Publicado: (2022) -
Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020) -
Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution
por: Fernández-Quintero, Monica L., et al.
Publicado: (2021) -
Conformational Shifts of Stacked Heteroaromatics: Vacuum vs. Water Studied by Machine Learning
por: Loeffler, Johannes R., et al.
Publicado: (2021)