Neuronal impact of patient-specific aberrant NRXN1α splicing

NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human induced pluripotent stem cell (hiPSC)-derived neurons represent well the diversity of NRXN1α alternative splicing observe...

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Detalles Bibliográficos
Autores principales: Flaherty, Erin, Zhu, Shijia, Barretto, Natalie, Cheng, Esther, Deans, Michael Peter, Fernando, Michael, Schrode, Nadine, Francoeur, Nancy, Antoine, Alesia, Alganem, Khaled, Halpern, Madeline, Deikus, Gintaras, Shah, Hardik, Fitzgerald, Megan, Ladran, Ian, Gochman, Peter, Rapoport, Judith, Tsankova, Nadejda, Mccullumsmith, Robert, Hoffman, Gabriel E., Sebra, Robert, Fang, Gang, Brennand, Kristen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451045/
https://www.ncbi.nlm.nih.gov/pubmed/31784728
http://dx.doi.org/10.1038/s41588-019-0539-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451045/
https://www.ncbi.nlm.nih.gov/pubmed/31784728
http://dx.doi.org/10.1038/s41588-019-0539-z

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