High affinity rigidified AT(2) receptor ligands with indane scaffolds

Rigidification of the isobutyl side chain of drug-like AT(2) receptor agonists and antagonists that are structurally related to the first reported selective AT(2) receptor agonist 1 (C21) delivered bioactive indane derivatives. Four enantiomer pairs were synthesized and the enantiomers were isolated...

Descripción completa

Detalles Bibliográficos
Autores principales: Wallinder, Charlotta, Sköld, Christian, Sundholm, Sara, Guimond, Marie-Odile, Yahiaoui, Samir, Lindeberg, Gunnar, Gallo-Payet, Nicole, Hallberg, Mathias, Alterman, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451071/
https://www.ncbi.nlm.nih.gov/pubmed/32904210
http://dx.doi.org/10.1039/c9md00402e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451071/
https://www.ncbi.nlm.nih.gov/pubmed/32904210
http://dx.doi.org/10.1039/c9md00402e

Ejemplares similares