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High affinity rigidified AT(2) receptor ligands with indane scaffolds

Rigidification of the isobutyl side chain of drug-like AT(2) receptor agonists and antagonists that are structurally related to the first reported selective AT(2) receptor agonist 1 (C21) delivered bioactive indane derivatives. Four enantiomer pairs were synthesized and the enantiomers were isolated...

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Detalles Bibliográficos
Autores principales:	Wallinder, Charlotta, Sköld, Christian, Sundholm, Sara, Guimond, Marie-Odile, Yahiaoui, Samir, Lindeberg, Gunnar, Gallo-Payet, Nicole, Hallberg, Mathias, Alterman, Mathias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451071/ https://www.ncbi.nlm.nih.gov/pubmed/32904210 http://dx.doi.org/10.1039/c9md00402e

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