Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread pain

The prevalence of chronic widespread pain (CWP) in people with HIV is high, yet the underlying mechanisms are elusive. Leukocytes synthesize the endogenous opioid, β-endorphin, within their endoplasmic reticulum (ER). When released into plasma, β-endorphin dampens nociception by binding to opioid re...

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Detalles Bibliográficos
Autores principales: Aggarwal, Saurabh, DeBerry, Jennifer J., Ahmad, Israr, Lynn, Prichard, Dewitte, Cary, Malik, Simran, Merlin, Jessica S., Goodin, Burel R., Heath, Sonya L., Matalon, Sadis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451624/
https://www.ncbi.nlm.nih.gov/pubmed/32828015
http://dx.doi.org/10.1016/j.redox.2020.101684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451624/
https://www.ncbi.nlm.nih.gov/pubmed/32828015
http://dx.doi.org/10.1016/j.redox.2020.101684

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