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A phase I dose-finding design with incorporation of historical information and adaptive shrinking boundaries
Although many novel phase I designs have been developed in recent years, few studies have discussed how to incorporate external information into dose-finding designs. In this paper, we first propose a new method for developing a phase I design, Bayesian optimal interval design (BOIN)[Liu S et al. (2...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451661/ https://www.ncbi.nlm.nih.gov/pubmed/32853204 http://dx.doi.org/10.1371/journal.pone.0237254 |