Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance

The E3 ubiquitin ligase FBW7 plays critical roles in multiple pathological and physiological processes. Here, we report that after high-fat diet (HFD) feeding for 16 weeks, myeloid-specific FBW7-deficient mice demonstrate increased redox stress, inflammatory responses and insulin resistance. Macroph...

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Detalles Bibliográficos
Autores principales: Wang, Cheng, Chao, Yuelin, Xu, Wenjing, Liu, Zhaoyu, Wang, Huan, Huang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451763/
https://www.ncbi.nlm.nih.gov/pubmed/32853822
http://dx.doi.org/10.1016/j.redox.2020.101688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451763/
https://www.ncbi.nlm.nih.gov/pubmed/32853822
http://dx.doi.org/10.1016/j.redox.2020.101688

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