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Deconvolving the contributions of cell-type heterogeneity on cortical gene expression
Complexity of cell-type composition has created much skepticism surrounding the interpretation of bulk tissue transcriptomic studies. Recent studies have shown that deconvolution algorithms can be applied to computationally estimate cell-type proportions from gene expression data of bulk blood sampl...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451979/ https://www.ncbi.nlm.nih.gov/pubmed/32804935 http://dx.doi.org/10.1371/journal.pcbi.1008120 |