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Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping
Pleiotropy—when a single mutation affects multiple traits—is a controversial topic with far-reaching implications. Pleiotropy plays a central role in debates about how complex traits evolve and whether biological systems are modular or are organized such that every gene has the potential to affect m...
Autores principales: | Geiler-Samerotte, Kerry A., Li, Shuang, Lazaris, Charalampos, Taylor, Austin, Ziv, Naomi, Ramjeawan, Chelsea, Paaby, Annalise B., Siegal, Mark L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451985/ https://www.ncbi.nlm.nih.gov/pubmed/32804946 http://dx.doi.org/10.1371/journal.pbio.3000836 |
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