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Systematic identification of functional SNPs interrupting 3’UTR polyadenylation signals
Alternative polyadenylation (APA) is emerging as a widespread regulatory layer since the majority of human protein-coding genes contain several polyadenylation (p(A)) sites in their 3’UTRs. By generating isoforms with different 3’UTR length, APA potentially affects mRNA stability, translation effici...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451987/ https://www.ncbi.nlm.nih.gov/pubmed/32804959 http://dx.doi.org/10.1371/journal.pgen.1008977 |