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Systematic identification of functional SNPs interrupting 3’UTR polyadenylation signals

Alternative polyadenylation (APA) is emerging as a widespread regulatory layer since the majority of human protein-coding genes contain several polyadenylation (p(A)) sites in their 3’UTRs. By generating isoforms with different 3’UTR length, APA potentially affects mRNA stability, translation effici...

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Detalles Bibliográficos
Autores principales: Shulman, Eldad David, Elkon, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451987/
https://www.ncbi.nlm.nih.gov/pubmed/32804959
http://dx.doi.org/10.1371/journal.pgen.1008977