Cargando…

Systematic identification of functional SNPs interrupting 3’UTR polyadenylation signals

Alternative polyadenylation (APA) is emerging as a widespread regulatory layer since the majority of human protein-coding genes contain several polyadenylation (p(A)) sites in their 3’UTRs. By generating isoforms with different 3’UTR length, APA potentially affects mRNA stability, translation effici...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shulman, Eldad David, Elkon, Ran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451987/ https://www.ncbi.nlm.nih.gov/pubmed/32804959 http://dx.doi.org/10.1371/journal.pgen.1008977

Ejemplares similares

Cell-type-specific analysis of alternative polyadenylation using single-cell transcriptomics data
por: Shulman, Eldad David, et al.
Publicado: (2019)

Genetic mapping of developmental trajectories for complex traits and diseases
por: Shulman, Eldad David, et al.
Publicado: (2021)

Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential
por: Malka, Yuval, et al.
Publicado: (2022)

UTR extension and alternate polyadenylation in neuroplasticity: an emerging paradigm?
por: Harrison, Benjamin J, et al.
Publicado: (2014)

Aberrant Ki‐67 expression through 3′UTR alternative polyadenylation in breast cancers
por: Yan, Hong, et al.
Publicado: (2018)

Identification and characterization of extensive intra-molecular associations between 3′-UTRs and their ORFs
por: Eldad, Naama, et al.
Publicado: (2008)

A Genome-wide Study of “Non-3UTR” Polyadenylation Sites in Arabidopsis thaliana
por: Guo, Cheng, et al.
Publicado: (2016)

Cigarette smoking-associated isoform switching and 3′ UTR lengthening via alternative polyadenylation
por: Xu, Zhonghui, et al.
Publicado: (2021)

Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites
por: de Prisco, Nicola, et al.
Publicado: (2023)

APA-Scan: detection and visualization of 3′-UTR alternative polyadenylation with RNA-seq and 3′-end-seq data
por: Fahmi, Naima Ahmed, et al.
Publicado: (2022)

E2F mediates enhanced alternative polyadenylation in proliferation
por: Elkon, Ran, et al.
Publicado: (2012)

Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
por: Zheng, Dinghai, et al.
Publicado: (2018)

Experimental Verification and Evolutionary Origin of 5′-UTR Polyadenylation Sites in Arabidopsis thaliana
por: Zhu, Yingdong, et al.
Publicado: (2018)

Mining the 3′UTR of Autism-implicated Genes for SNPs Perturbing MicroRNA Regulation
por: Vaishnavi, Varadharajan, et al.
Publicado: (2014)

ElrA binding to the 3′UTR of cyclin E1 mRNA requires polyadenylation elements
por: Slevin, Michael K., et al.
Publicado: (2007)

SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
por: Rykova, Elena, et al.
Publicado: (2022)

Nudt21-mediated alternative polyadenylation of HMGA2 3′-UTR impairs stemness of human tendon stem cell
por: Sun, Yangbai, et al.
Publicado: (2020)

RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3′ UTRs
por: Di Giammartino, Dafne Campigli, et al.
Publicado: (2014)

A Polymorphic 3’UTR Element in ATP1B1 Regulates Alternative Polyadenylation and Is Associated with Blood Pressure
por: Prasad, Megana K., et al.
Publicado: (2013)

Shortening of 3′ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism
por: Burri, Dominik, et al.
Publicado: (2021)

Using population-scale transcriptomic and genomic data to map 3′ UTR alternative polyadenylation quantitative trait loci
por: Zou, Xudong, et al.
Publicado: (2022)

SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels
por: Schwich, Oliver Daniel, et al.
Publicado: (2021)

3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells
por: Hoffman, Yonit, et al.
Publicado: (2016)

3′aQTL-atlas: an atlas of 3′UTR alternative polyadenylation quantitative trait loci across human normal tissues
por: Cui, Ya, et al.
Publicado: (2021)

Brain-specific promoter and polyadenylation sites of the β-adducin pre-mRNA generate an unusually long 3′-UTR
por: Costessi, Luisa, et al.
Publicado: (2006)

Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening
por: Beaudoin, Jean-Denis, et al.
Publicado: (2013)

Corrigendum: Shortening of 3′ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism
por: Burri, Dominik, et al.
Publicado: (2023)

mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus
por: Bergant, Valter, et al.
Publicado: (2023)

38766 Massively Parallel Reporter Assay Reveals Functional Impact of 3™-UTR SNPs Associated with Neurological and Psychiatric Disorders
por: Chen, Andy B., et al.
Publicado: (2021)

Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33
por: Schönemann, Lars, et al.
Publicado: (2014)

Two Novel SNPs in ATXN3 3’ UTR May Decrease Age at Onset of SCA3/MJD in Chinese Patients
por: Long, Zhe, et al.
Publicado: (2015)

Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells
por: Shi, Xinglong, et al.
Publicado: (2021)

Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes
por: Chen, Meng, et al.
Publicado: (2021)

The C. elegans 3′ UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3′-UTR biology, and miRNA targeting
por: Steber, Hannah S., et al.
Publicado: (2019)

Impact of the Interaction between 3′-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes
por: Wei, Rongrong, et al.
Publicado: (2012)

Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3′-UTRs
por: Kubo, Tomohiro, et al.
Publicado: (2006)

VIRMA mediates preferential m(6)A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
por: Yue, Yanan, et al.
Publicado: (2018)

The Computational Analysis Conducted on miRNA Target Sites in Association with SNPs at 3’UTR of ADHD-implicated Genes
por: Abdi, Adel, et al.
Publicado: (2020)

APC gene 3′UTR SNPs and interactions with environmental factors are correlated with risk of colorectal cancer in Chinese Han population
por: Ying, Rongbiao, et al.
Publicado: (2020)

AZFa Y gene, DDX3Y, evolved novel testis transcript variants in primates with proximal 3´UTR polyadenylation for germ cell specific translation
por: Vogt, P. H., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_optts291tpc0t73dn0iesdbjv2