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Generation and characterization of keap1a- and keap1b-knockout zebrafish

The Keap1–Nrf2 pathway is an evolutionarily conserved mechanism that protects cells from oxidative stress and electrophiles. Under homeostatic conditions, Keap1 interacts with Nrf2 and leads to its rapid proteasomal degradation, but when cells are exposed to oxidative stress/electrophiles, Keap1 sen...

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Detalles Bibliográficos
Autores principales: Nguyen, Vu Thanh, Bian, Lixuan, Tamaoki, Junya, Otsubo, Shiro, Muratani, Masafumi, Kawahara, Atsuo, Kobayashi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452054/
https://www.ncbi.nlm.nih.gov/pubmed/32828016
http://dx.doi.org/10.1016/j.redox.2020.101667