Cargando…
Generation and characterization of keap1a- and keap1b-knockout zebrafish
The Keap1–Nrf2 pathway is an evolutionarily conserved mechanism that protects cells from oxidative stress and electrophiles. Under homeostatic conditions, Keap1 interacts with Nrf2 and leads to its rapid proteasomal degradation, but when cells are exposed to oxidative stress/electrophiles, Keap1 sen...
Autores principales: | Nguyen, Vu Thanh, Bian, Lixuan, Tamaoki, Junya, Otsubo, Shiro, Muratani, Masafumi, Kawahara, Atsuo, Kobayashi, Makoto |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452054/ https://www.ncbi.nlm.nih.gov/pubmed/32828016 http://dx.doi.org/10.1016/j.redox.2020.101667 |
Ejemplares similares
-
Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish
por: Bian, Lixuan, et al.
Publicado: (2023) -
Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish
por: Nguyen, Vu Thanh, et al.
Publicado: (2016) -
Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
por: Copple, Ian M., et al.
Publicado: (2010) -
Keap1 mutations in lung cancer patients
por: SASAKI, HIDEFUMI, et al.
Publicado: (2013) -
The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)