Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations. Inspired by our previous efforts in designing antitumor evodiamine derivatives, herein selective histone deacetylase 1 (HDAC1)...

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Detalles Bibliográficos
Autores principales: Huang, Yahui, Chen, Shuqiang, Wu, Shanchao, Dong, Guoqiang, Sheng, Chunquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452071/
https://www.ncbi.nlm.nih.gov/pubmed/32874829
http://dx.doi.org/10.1016/j.apsb.2019.11.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452071/
https://www.ncbi.nlm.nih.gov/pubmed/32874829
http://dx.doi.org/10.1016/j.apsb.2019.11.011

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