Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Small interfering RNAs (siRNAs) have potential to silence virtually any disease-causing gene but require chemical modifications for delivery to the tissue and cell of interest. Previously, we demonstrated that asymmetric, phosphorothioate (PS)-modified, chemically stabilized, cholesterol-conjugated...

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Detalles Bibliográficos
Autores principales: Ly, Socheata, Echeverria, Dimas, Sousa, Jacquelyn, Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452107/
https://www.ncbi.nlm.nih.gov/pubmed/32818923
http://dx.doi.org/10.1016/j.omtn.2020.07.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452107/
https://www.ncbi.nlm.nih.gov/pubmed/32818923
http://dx.doi.org/10.1016/j.omtn.2020.07.029

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