HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Mitophagy was evaluated by measuring the changes of mitophagy flux, mitochondria DNA copy number, and the change...

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Detalles Bibliográficos
Autores principales: Fu, Zong-Jie, Wang, Zhi-Yu, Xu, Lian, Chen, Xiao-Hui, Li, Xiang-Xiao, Liao, Wei-Tang, Ma, Hong-Kun, Jiang, Meng-Di, Xu, Ting-Ting, Xu, Jing, Shen, Yan, Song, Bei, Gao, Ping-Jin, Han, Wei-Qing, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452120/
https://www.ncbi.nlm.nih.gov/pubmed/32829253
http://dx.doi.org/10.1016/j.redox.2020.101671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452120/
https://www.ncbi.nlm.nih.gov/pubmed/32829253
http://dx.doi.org/10.1016/j.redox.2020.101671

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