CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations

CRISPR-Cas9-mediated gene knockout and base-editing-associated induction of STOP codons (iSTOP) have been widely used to exterminate the function of a coding gene, while they have been reported to exhibit side effects. In this study, we propose a novel and practical alternative method referred to as...

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Detalles Bibliográficos
Autores principales: Chen, Siyu, Xie, Wanhua, Liu, Zhiquan, Shan, Huanhuan, Chen, Mao, Song, Yuning, Yu, Hao, Lai, Liangxue, Li, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452150/
https://www.ncbi.nlm.nih.gov/pubmed/32854061
http://dx.doi.org/10.1016/j.omtn.2020.07.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452150/
https://www.ncbi.nlm.nih.gov/pubmed/32854061
http://dx.doi.org/10.1016/j.omtn.2020.07.037

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