Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure

Large clinical trials designed to test the efficacy of vagus nerve stimulation (VNS) in patients with heart failure did not demonstrate benefits with respect to the primary endpoints. The nonselective nature of VNS may account for the failure to translate promising results of preclinical and earlier...

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Detalles Bibliográficos
Autores principales: Machhada, Asif, Hosford, Patrick S., Dyson, Alex, Ackland, Gareth L., Mastitskaya, Svetlana, Gourine, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452237/
https://www.ncbi.nlm.nih.gov/pubmed/32875170
http://dx.doi.org/10.1016/j.jacbts.2020.06.002
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author Machhada, Asif
Hosford, Patrick S.
Dyson, Alex
Ackland, Gareth L.
Mastitskaya, Svetlana
Gourine, Alexander V.
author_facet Machhada, Asif
Hosford, Patrick S.
Dyson, Alex
Ackland, Gareth L.
Mastitskaya, Svetlana
Gourine, Alexander V.
author_sort Machhada, Asif
collection PubMed
description Large clinical trials designed to test the efficacy of vagus nerve stimulation (VNS) in patients with heart failure did not demonstrate benefits with respect to the primary endpoints. The nonselective nature of VNS may account for the failure to translate promising results of preclinical and earlier clinical studies. This study showed that optogenetic stimulation of vagal pre-ganglionic neurons transduced to express light-sensitive channels preserved left ventricular function and exercise capacity in a rat model of myocardial infarction−induced heart failure. These data suggested that stimulation of vagal efferent activity is critically important to deliver the therapeutic benefit of VNS in heart failure.
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spelling pubmed-74522372020-08-31 Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure Machhada, Asif Hosford, Patrick S. Dyson, Alex Ackland, Gareth L. Mastitskaya, Svetlana Gourine, Alexander V. JACC Basic Transl Sci PRECLINICAL RESEARCH Large clinical trials designed to test the efficacy of vagus nerve stimulation (VNS) in patients with heart failure did not demonstrate benefits with respect to the primary endpoints. The nonselective nature of VNS may account for the failure to translate promising results of preclinical and earlier clinical studies. This study showed that optogenetic stimulation of vagal pre-ganglionic neurons transduced to express light-sensitive channels preserved left ventricular function and exercise capacity in a rat model of myocardial infarction−induced heart failure. These data suggested that stimulation of vagal efferent activity is critically important to deliver the therapeutic benefit of VNS in heart failure. Elsevier 2020-07-15 /pmc/articles/PMC7452237/ /pubmed/32875170 http://dx.doi.org/10.1016/j.jacbts.2020.06.002 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle PRECLINICAL RESEARCH
Machhada, Asif
Hosford, Patrick S.
Dyson, Alex
Ackland, Gareth L.
Mastitskaya, Svetlana
Gourine, Alexander V.
Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure
title Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure
title_full Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure
title_fullStr Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure
title_full_unstemmed Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure
title_short Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure
title_sort optogenetic stimulation of vagal efferent activity preserves left ventricular function in experimental heart failure
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452237/
https://www.ncbi.nlm.nih.gov/pubmed/32875170
http://dx.doi.org/10.1016/j.jacbts.2020.06.002
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