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MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce rapid and sustained tumor regression, a phenomenon...

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Detalles Bibliográficos
Autores principales: Dhanasekaran, Renumathy, Park, Jangho, Yevtodiyenko, Alekesey, Bellovin, David I., Adam, Stacey J., KD, Anand Rajan, Gabay, Meital, Fernando, Hanan, Arzeno, Julia, Arjunan, Vinodhini, Gryanzov, Sergei, Felsher, Dean W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452286/
https://www.ncbi.nlm.nih.gov/pubmed/32805488
http://dx.doi.org/10.1016/j.omtn.2020.07.008