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Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation
In bacteria, the dissociable σ subunit of the RNA polymerase (RNAP) is responsible for initiating RNA synthesis from specific DNA sites. As nascent RNA grows, downstream DNA unwinds and is pulled into the RNAP, causing stress accumulation and initiation complex destabilization. Processive transcript...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452309/ https://www.ncbi.nlm.nih.gov/pubmed/32829286 http://dx.doi.org/10.1016/j.isci.2020.101445 |