Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

Events at a receptor ectodomain affect the intracellular domain conformation, activating signal transduction (out-to-in conformational effects). We investigated the reverse direction (in-to-out) where the intracellular domain may impact on ectodomain conformation. The primary sequences of naturally...

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Detalles Bibliográficos
Autores principales: Brahimi, Fouad, Galan, Alba, Jmaeff, Sean, Barcelona, Pablo F., De Jay, Nicolas, Dejgaard, Kurt, Young, Jason C., Kleinman, Claudia L., Thomas, David Y., Saragovi, H. Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452315/
https://www.ncbi.nlm.nih.gov/pubmed/32829283
http://dx.doi.org/10.1016/j.isci.2020.101447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452315/
https://www.ncbi.nlm.nih.gov/pubmed/32829283
http://dx.doi.org/10.1016/j.isci.2020.101447

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