Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration

Despite the progress made in AAV-based gene therapy targeting different organ systems, lung-targeted gene therapy using AAV vectors has not been effective, mostly due to the poor transduction and un-sustained gene expression in airway epithelium. Furthermore, concerns over possible harmful insertion...

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Detalles Bibliográficos
Autores principales: Colon-Cortes, Yanerys, Hasan, Mutasim Abu, Aslanidi, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452375/
https://www.ncbi.nlm.nih.gov/pubmed/32904225
http://dx.doi.org/10.1016/j.gene.2020.100037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452375/
https://www.ncbi.nlm.nih.gov/pubmed/32904225
http://dx.doi.org/10.1016/j.gene.2020.100037

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