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Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration
Despite the progress made in AAV-based gene therapy targeting different organ systems, lung-targeted gene therapy using AAV vectors has not been effective, mostly due to the poor transduction and un-sustained gene expression in airway epithelium. Furthermore, concerns over possible harmful insertion...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452375/ https://www.ncbi.nlm.nih.gov/pubmed/32904225 http://dx.doi.org/10.1016/j.gene.2020.100037 |