Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development

BACKGOUND: The potential of a single progenitor cell to establish and maintain long-term protective T-cell immunity in humans is unknown. For genetic disorders disabling T-cell immunity, somatic reversion was shown to support limited T-cell development attenuating the clinical phenotype. However, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Kury, Patrick, Führer, Marita, Fuchs, Sebastian, Lorenz, Myriam R., Giorgetti, Orlando Bruno, Bakhtiar, Shahrzad, Frei, Andreas P., Fisch, Paul, Boehm, Thomas, Schwarz, Klaus, Speckmann, Carsten, Ehl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452388/
https://www.ncbi.nlm.nih.gov/pubmed/32841837
http://dx.doi.org/10.1016/j.ebiom.2020.102961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452388/
https://www.ncbi.nlm.nih.gov/pubmed/32841837
http://dx.doi.org/10.1016/j.ebiom.2020.102961

Ejemplares similares