CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease

BACKGROUND: Cholinergic neuronal loss is one of the hallmarks of AD related neurodegeneration; however, preclinical promise of α7 nAChR drugs failed to translate into humans. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of α7 nAChR and was unaccounted for in preclinical models. ME...

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Detalles Bibliográficos
Autores principales: Szigeti, Kinga, Ihnatovych, Ivanna, Birkaya, Barbara, Chen, Ziqiang, Ouf, Aya, Indurthi, Dinesh C., Bard, Jonathan E., Kann, Julien, Adams, Alexandrea, Chaves, Lee, Sule, Norbert, Reisch, Joan S., Pavlik, Valory, Benedict, Ralph H.B., Auerbach, Anthony, Wilding, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452451/
https://www.ncbi.nlm.nih.gov/pubmed/32818803
http://dx.doi.org/10.1016/j.ebiom.2020.102892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452451/
https://www.ncbi.nlm.nih.gov/pubmed/32818803
http://dx.doi.org/10.1016/j.ebiom.2020.102892

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