Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity

Entada africana is used in non-conventional medicine for the management of liver ailments. A fraction, designated EaF10 (methylene chloride/methanol 90:10, v/v) with promising hepatoprotective activity has been isolated. Since the mechanisms underlying EaF10 hepatoprotective action remain unknown, t...

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Detalles Bibliográficos
Autores principales: Kouam, Arnaud Fondjo, Owona, Brice Ayissi, Fifen, Rodrigue, Njayou, Frédéric Nico, Moundipa, Paul Fewou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452572/
https://www.ncbi.nlm.nih.gov/pubmed/32904230
http://dx.doi.org/10.1016/j.heliyon.2020.e04602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452572/
https://www.ncbi.nlm.nih.gov/pubmed/32904230
http://dx.doi.org/10.1016/j.heliyon.2020.e04602

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