Cargando…

BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations

Immunotherapy in pancreatic ductal adenocarcinoma (PDAC) treatment faces serious challenges, due particularly to the poor immunogenicity. Cancer cell-derived small extracellular vesicles (sEVs) play important roles in damaging the immune system. However, the effects of pancreatic cancer-derived sEVs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Tao, Jia, Shengnan, Ding, Guoping, Ping, Dongnan, Zhou, Liangjing, Zhou, Senhao, Cao, Liping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452591/ https://www.ncbi.nlm.nih.gov/pubmed/32798974 http://dx.doi.org/10.1016/j.isci.2020.101431

Ejemplares similares

Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
por: DU, JIAN, et al.
Publicado: (2012)

Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
por: Du, Jian, et al.
Publicado: (2023)

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
por: Hannon, Gary, et al.
Publicado: (2020)

Intracellular Distributing and Interferon-γ Secretion of Human Interleukin-18 in BxPC-3 Cells
por: Yang, Jin, et al.
Publicado: (2014)

Implications of Targeted Genomic Disruption of β-Catenin in BxPC-3 Pancreatic Adenocarcinoma Cells
por: Olsen, Petter Angell, et al.
Publicado: (2014)

Oridonin alters the expression profiles of MicroRNAs in BxPC-3 human pancreatic cancer cells
por: Gui, Zhifang, et al.
Publicado: (2015)

Proton Therapy, Magnetic Nanoparticles and Hyperthermia as Combined Treatment for Pancreatic BxPC3 Tumor Cells
por: Brero, Francesca, et al.
Publicado: (2023)

Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells
por: Liu, Hao, et al.
Publicado: (2017)

Effects of Metallic and Carbon-Based Nanomaterials on Human Pancreatic Cancer Cell Lines AsPC-1 and BxPC-3
por: Wójcik, Barbara, et al.
Publicado: (2021)

Enhanced tumor targeting of cRGD peptide-conjugated albumin nanoparticles in the BxPC-3 cell line
por: Yu, Xinzhe, et al.
Publicado: (2016)

Phenolic alkaloids from Menispermum dauricum inhibits BxPC-3 pancreatic cancer cells by blocking of Hedgehog signaling pathway
por: Zhou, Zhong-guang, et al.
Publicado: (2015)

Expression profiling of wild type and β-catenin gene disrupted human BxPC-3 pancreatic adenocarcinoma cells
por: Olsen, Petter Angell, et al.
Publicado: (2015)

Cytotoxic effect of Efavirenz in BxPC-3 pancreatic cancer cells is based on oxidative stress and is synergistic with ionizing radiation
por: Hecht, Markus, et al.
Publicado: (2018)

Silencing NEDD9 by lentivirus-delivered shRNA inhibits the growth of BxPC-3 cells in vitro and in vivo
por: Wu, Tielong, et al.
Publicado: (2019)

Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
por: Tanaka, Hiromitsu, et al.
Publicado: (2022)

BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition
por: LEGENDRE, ONICA, et al.
Publicado: (2014)

Dickkopf-related protein 3 alters aerobic glycolysis in pancreatic cancer BxPC-3 cells, promoting CD4(+) T-cell activation and function
por: Guo, Qingqu, et al.
Publicado: (2021)

MS-5, a Naphthalene Derivative, Induces Apoptosis in Human Pancreatic Cancer BxPC-3 Cells by Modulating Reactive Oxygen Species
por: Giri, Suman, et al.
Publicado: (2023)

Salidroside ameliorated hypoxia‐induced tumorigenesis of BxPC‐3 cells via downregulating hypoxia‐inducible factor (HIF)‐1α and LOXL2
por: Chen, Xiaoping, et al.
Publicado: (2019)

The natural sulfoglycolipid derivative SQAP improves the therapeutic efficacy of tissue factor-targeted radioimmunotherapy in the stroma-rich pancreatic cancer model BxPC-3
por: Takakusagi, Yoichi, et al.
Publicado: (2021)

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma
por: Mandys, Václav, et al.
Publicado: (2023)

Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA
por: Yang, Xiaoyu, et al.
Publicado: (2018)

Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor beta-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3
por: Zhu, Liang, et al.
Publicado: (2012)

ASF-4-1 fibroblast-rich culture increases chemoresistance and mTOR expression of pancreatic cancer BxPC-3 cells at the invasive front in vitro, and promotes tumor growth and invasion in vivo
por: FUJIWARA, MASAYA, et al.
Publicado: (2016)

Foxp3 Post-translational Modifications and Treg Suppressive Activity
por: Deng, Guoping, et al.
Publicado: (2019)

Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with (90)Y-Labeled Fully Human Anti-CD147 Monoclonal Antibody 059-053 in a BxPC-3 Xenograft Mouse Model of Refractory Pancreatic Cancer
por: Sugyo, Aya, et al.
Publicado: (2018)

Down-expression of CD36 in pancreatic adenocarcinoma and its correlation with clinicopathological features and prognosis
por: Jia, Shengnan, et al.
Publicado: (2018)

Foxp3 Instability Helps tTregs Distinguish Self and Non-self
por: Zhang, Zhongmei, et al.
Publicado: (2019)

FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases
por: Nie, Jia, et al.
Publicado: (2015)

Foxp3(+) Tregs are recruited to the retina to repair pathological angiogenesis
por: Deliyanti, Devy, et al.
Publicado: (2017)

Foxp3 Molecular Dynamics in Treg in Juvenile Idiopathic Arthritis
por: Copland, Alastair, et al.
Publicado: (2018)

Changes in Natural Foxp3(+)Treg but Not Mucosally-Imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the Circulation of Celiac Disease Patients
por: van Leeuwen, Marieke A., et al.
Publicado: (2013)

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1
por: van Loosdregt, Jorg, et al.
Publicado: (2011)

Cancer-FOXP3 directly activated CCL5 to recruit FOXP3(+)Treg cells in pancreatic ductal adenocarcinoma
por: Wang, X, et al.
Publicado: (2017)

The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells
por: Ghosh, Sayantani, et al.
Publicado: (2018)

High Expression of P38α and Preoperative Carbohydrate Antigen 19-9 Indicate Poor Prognosis in Patients with Pancreatic Ductal Adenocarcinoma
por: Chen, Jionghuang, et al.
Publicado: (2018)

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans
por: Janson, Peter C. J., et al.
Publicado: (2008)

Stability and Maintenance of Foxp3(+) Treg Cells in Non-lymphoid Microenvironments
por: Korn, Thomas, et al.
Publicado: (2019)

Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications
por: Dong, Yi, et al.
Publicado: (2021)

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
por: Xu, Yuxiu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_stbc4fbncoligvn1mejseorbkq