Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity

BACKGROUND: PARP inhibitors are active in various tumour types beyond BRCA-mutant cancers, but their activity and molecular correlates in colorectal cancer (CRC) are not well studied. METHODS: Mutations and genome-wide mutational patterns associated with homologous recombination deficiency (HRD) wer...

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Detalles Bibliográficos
Autores principales: Smeby, Jørgen, Kryeziu, Kushtrim, Berg, Kaja C.G., Eilertsen, Ina A., Eide, Peter W., Johannessen, Bjarne, Guren, Marianne G., Nesbakken, Arild, Bruun, Jarle, Lothe, Ragnhild A., Sveen, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452640/
https://www.ncbi.nlm.nih.gov/pubmed/32799124
http://dx.doi.org/10.1016/j.ebiom.2020.102923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452640/
https://www.ncbi.nlm.nih.gov/pubmed/32799124
http://dx.doi.org/10.1016/j.ebiom.2020.102923

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