Crosslinked Extracellular Matrix Stiffens Human Trabecular Meshwork Cells Via Dysregulating β-catenin and YAP/TAZ Signaling Pathways

PURPOSE: The purpose of this study was to determine whether genipin-induced crosslinked cell-derived matrix (XCDM) precipitates fibrotic phenotypes in human trabecular meshwork (hTM) cells by dysregulating β-catenin and Yes-associated protein (YAP)/ transcriptional coactivator with PDZ-binding motif...

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Detalles Bibliográficos
Autores principales: Yemanyi, Felix, Vranka, Janice, Raghunathan, Vijay Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452853/
https://www.ncbi.nlm.nih.gov/pubmed/32832971
http://dx.doi.org/10.1167/iovs.61.10.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452853/
https://www.ncbi.nlm.nih.gov/pubmed/32832971
http://dx.doi.org/10.1167/iovs.61.10.41

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