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HIV-1 Virologic Rebound Due to Coadministration of Divalent Cations and Bictegravir

A potential drug-drug interaction exists between divalent and trivalent cations (Ca(2+), Fe(3+), Mg(2+), Al(3+), Zn(2+)) and HIV-1 integrase strand transfer inhibitors (INSTIs). There are limited case reports describing the clinical significance of this potential interaction and none to our knowledg...

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Detalles Bibliográficos
Autores principales: Rock, Alex E., DeMarais, Patricia L., Vergara-Rodriguez, Pamala T., Max, Blake E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452960/
https://www.ncbi.nlm.nih.gov/pubmed/32623580
http://dx.doi.org/10.1007/s40121-020-00307-4