Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy

PURPOSE: To evaluate the efficacy of Library of Integrated Network-based Cellular Signatures (LINCS) perturbagen prediction software to identify small molecules that revert pathologic gene signature and alter disease phenotype in orbital adipose stem cells (OASCs) derived from patients with thyroid-...

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Detalles Bibliográficos
Autores principales: Lee, John Y., Gallo, Ryan A., Ledon, Paul J., Tao, Wensi, Tse, David T., Pelaez, Daniel, Wester, Sara T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453043/
https://www.ncbi.nlm.nih.gov/pubmed/32908802
http://dx.doi.org/10.1167/tvst.9.9.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453043/
https://www.ncbi.nlm.nih.gov/pubmed/32908802
http://dx.doi.org/10.1167/tvst.9.9.39

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