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Distinct macrophage phenotypes skewed by local granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis

OBJECTIVE: To determine the presence and spatial distribution of different macrophage phenotypes, governed by granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) skewing signals, in giant cell arteritis (GCA) lesions. METHODS: Temporal artery bi...

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Detalles Bibliográficos
Autores principales: Jiemy, William F, van Sleen, Yannick, van der Geest, Kornelis SM, ten Berge, Hilde A, Abdulahad, Wayel H, Sandovici, Maria, Boots, Annemieke MH, Heeringa, Peter, Brouwer, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453134/
https://www.ncbi.nlm.nih.gov/pubmed/32884747
http://dx.doi.org/10.1002/cti2.1164