Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

BACKGROUND: DNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly coordinated regulation. Here, we identify 818 genes that affect DNA methylation patterns in blood using large-scale population genomics data. RESULTS: By em...

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Detalles Bibliográficos
Autores principales: Hop, Paul J., Luijk, René, Daxinger, Lucia, van Iterson, Maarten, Dekkers, Koen F., Jansen, Rick, van Meurs, Joyce B. J., ’t Hoen, Peter A. C., Ikram, M. Arfan, van Greevenbroek, Marleen M. J., Boomsma, Dorret I., Slagboom, P. Eline, Veldink, Jan H., van Zwet, Erik W., Heijmans, Bastiaan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453518/
https://www.ncbi.nlm.nih.gov/pubmed/32859263
http://dx.doi.org/10.1186/s13059-020-02114-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453518/
https://www.ncbi.nlm.nih.gov/pubmed/32859263
http://dx.doi.org/10.1186/s13059-020-02114-z

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