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An allosteric pathway explains beneficial fitness in yeast for long‐range mutations in an essential TIM barrel enzyme
Protein evolution proceeds by a complex response of organismal fitness to mutations that can simultaneously affect protein stability, structure, and enzymatic activity. To probe the relationship between genotype and phenotype, we chose a fundamental paradigm for protein evolution, folding, and desig...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454521/ https://www.ncbi.nlm.nih.gov/pubmed/32643222 http://dx.doi.org/10.1002/pro.3911 |