Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design

Large-scale re-engineering of synonymous sites is a promising strategy to generate vaccines either through synthesis of attenuated viruses or via codon-optimized genes in DNA vaccines. Attenuation typically relies on deoptimization of codon pairs and maximization of CpG dinucleotide frequencies. So...

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Detalles Bibliográficos
Autores principales: Rice, Alan M, Castillo Morales, Atahualpa, Ho, Alexander T, Mordstein, Christine, Mühlhausen, Stefanie, Watson, Samir, Cano, Laura, Young, Bethan, Kudla, Grzegorz, Hurst, Laurence D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454790/
https://www.ncbi.nlm.nih.gov/pubmed/32687176
http://dx.doi.org/10.1093/molbev/msaa188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454790/
https://www.ncbi.nlm.nih.gov/pubmed/32687176
http://dx.doi.org/10.1093/molbev/msaa188

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