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Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis

PURPOSE: This study investigated nicotine dependence as an independent risk factor for upper aerodigestive tract (UADT) cancers, including lung and head and neck cancers (HNC). The study aimed to isolate the direct effect of nicotine dependence, independent of tobacco smoking. METHODS: A case-contro...

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Autores principales: Thomas, Sera, Carroll, June C., Brown, M. Catherine, Chen, Zhou, Mirshams, Maryam, Patel, Devalben, Boyd, Kevin, Pierre, Andrew, Goldstein, David P., Giuliani, Meredith E., Xu, Wei, Eng, Lawson, Khodayari Moez, Elham, Liu, Geoffrey, Hung, Rayjean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454981/
https://www.ncbi.nlm.nih.gov/pubmed/32857771
http://dx.doi.org/10.1371/journal.pone.0237723
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author Thomas, Sera
Carroll, June C.
Brown, M. Catherine
Chen, Zhou
Mirshams, Maryam
Patel, Devalben
Boyd, Kevin
Pierre, Andrew
Goldstein, David P.
Giuliani, Meredith E.
Xu, Wei
Eng, Lawson
Khodayari Moez, Elham
Liu, Geoffrey
Hung, Rayjean J.
author_facet Thomas, Sera
Carroll, June C.
Brown, M. Catherine
Chen, Zhou
Mirshams, Maryam
Patel, Devalben
Boyd, Kevin
Pierre, Andrew
Goldstein, David P.
Giuliani, Meredith E.
Xu, Wei
Eng, Lawson
Khodayari Moez, Elham
Liu, Geoffrey
Hung, Rayjean J.
author_sort Thomas, Sera
collection PubMed
description PURPOSE: This study investigated nicotine dependence as an independent risk factor for upper aerodigestive tract (UADT) cancers, including lung and head and neck cancers (HNC). The study aimed to isolate the direct effect of nicotine dependence, independent of tobacco smoking. METHODS: A case-control study with a total of 4957 participants was conducted in Ontario, Canada, of which 2964 categorized as either current or former smokers were used in the analysis. Nicotine dependence of ever-smokers (2360 UADT cases and 604 controls) was measured using the Fagerström Test for Nicotine Dependence. Using mediation analyses and adjusted logistic regression models, we decomposed the direct effect of nicotine dependence and the mediated effect of smoking duration to quantify the risks of lung and HNC. The role of human papillomavirus (HPV) and cancer subtypes were assessed. RESULTS: Most individual nicotine dependence behaviours showed positive associations with lung cancer with approximately 1.8 to 3.5-fold risk increase, and to lesser extent with 1.4 to 2.3-fold risk for HNC. Nicotine dependence is partially accountable for increased risks of lung cancer (OR = 1.20, 95%CI = 1.13–1.28) and HNC (1.12, 95%CI = 1.04–1.19). Nicotine dependence had a greater effect on the risk of HPV-negative oropharyngeal cancer (OR = 3.06, 95%CI = 1.65–5.66) in comparison to HPV-positive oropharyngeal cancer (OR = 1.05, 95%CI = 0.67–1.65). The direct effects of nicotine dependence remained significant after accounting for cumulative tobacco exposures. CONCLUSION: Nicotine dependence increases the risks of lung and HNC cancers after accounting for tobacco smoking, suggesting potential toxic effects of nicotine. These results are informative for the safety consideration of nicotine exposures.
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spelling pubmed-74549812020-09-02 Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis Thomas, Sera Carroll, June C. Brown, M. Catherine Chen, Zhou Mirshams, Maryam Patel, Devalben Boyd, Kevin Pierre, Andrew Goldstein, David P. Giuliani, Meredith E. Xu, Wei Eng, Lawson Khodayari Moez, Elham Liu, Geoffrey Hung, Rayjean J. PLoS One Research Article PURPOSE: This study investigated nicotine dependence as an independent risk factor for upper aerodigestive tract (UADT) cancers, including lung and head and neck cancers (HNC). The study aimed to isolate the direct effect of nicotine dependence, independent of tobacco smoking. METHODS: A case-control study with a total of 4957 participants was conducted in Ontario, Canada, of which 2964 categorized as either current or former smokers were used in the analysis. Nicotine dependence of ever-smokers (2360 UADT cases and 604 controls) was measured using the Fagerström Test for Nicotine Dependence. Using mediation analyses and adjusted logistic regression models, we decomposed the direct effect of nicotine dependence and the mediated effect of smoking duration to quantify the risks of lung and HNC. The role of human papillomavirus (HPV) and cancer subtypes were assessed. RESULTS: Most individual nicotine dependence behaviours showed positive associations with lung cancer with approximately 1.8 to 3.5-fold risk increase, and to lesser extent with 1.4 to 2.3-fold risk for HNC. Nicotine dependence is partially accountable for increased risks of lung cancer (OR = 1.20, 95%CI = 1.13–1.28) and HNC (1.12, 95%CI = 1.04–1.19). Nicotine dependence had a greater effect on the risk of HPV-negative oropharyngeal cancer (OR = 3.06, 95%CI = 1.65–5.66) in comparison to HPV-positive oropharyngeal cancer (OR = 1.05, 95%CI = 0.67–1.65). The direct effects of nicotine dependence remained significant after accounting for cumulative tobacco exposures. CONCLUSION: Nicotine dependence increases the risks of lung and HNC cancers after accounting for tobacco smoking, suggesting potential toxic effects of nicotine. These results are informative for the safety consideration of nicotine exposures. Public Library of Science 2020-08-28 /pmc/articles/PMC7454981/ /pubmed/32857771 http://dx.doi.org/10.1371/journal.pone.0237723 Text en © 2020 Thomas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Thomas, Sera
Carroll, June C.
Brown, M. Catherine
Chen, Zhou
Mirshams, Maryam
Patel, Devalben
Boyd, Kevin
Pierre, Andrew
Goldstein, David P.
Giuliani, Meredith E.
Xu, Wei
Eng, Lawson
Khodayari Moez, Elham
Liu, Geoffrey
Hung, Rayjean J.
Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis
title Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis
title_full Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis
title_fullStr Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis
title_full_unstemmed Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis
title_short Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis
title_sort nicotine dependence as a risk factor for upper aerodigestive tract (uadt) cancers: a mediation analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454981/
https://www.ncbi.nlm.nih.gov/pubmed/32857771
http://dx.doi.org/10.1371/journal.pone.0237723
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