MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC

Triple-negative breast cancers (TNBCs) are heterogeneous and aggressive, with high mortality rates. TNBCs frequently respond to chemotherapy, yet many patients develop chemoresistance. The molecular basis and roles for tumor cell–stromal crosstalk in establishing chemoresistance are complex and larg...

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Detalles Bibliográficos
Autores principales: Franklin, Derek A., Sharick, Joe T., Ericsson-Gonzalez, Paula I., Sanchez, Violeta, Dean, Phillip T., Opalenik, Susan R., Cairo, Stefano, Judde, Jean-Gabriel, Lewis, Michael T., Chang, Jenny C., Sanders, Melinda E., Cook, Rebecca S., Skala, Melissa C., Bordeaux, Jennifer, Orozco Bender, Jehovana, Vaupel, Christine, Geiss, Gary, Hinerfeld, Douglas, Balko, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455066/
https://www.ncbi.nlm.nih.gov/pubmed/32634121
http://dx.doi.org/10.1172/jci.insight.134290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455066/
https://www.ncbi.nlm.nih.gov/pubmed/32634121
http://dx.doi.org/10.1172/jci.insight.134290

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