Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity

A tumor blood vessel is a key regulator of tissue perfusion, immune cell trafficking, cancer metastasis, and therapeutic responsiveness. mTORC1 is a signaling node downstream of multiple angiogenic factors in the endothelium. However, mTORC1 inhibitors have limited efficacy in most solid tumors, in...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shan, Raybuck, Ariel, Shiuan, Eileen, Cho, Sung Hoon, Wang, Qingfei, Brantley-Sieders, Dana M., Edwards, Deanna, Allaman, Margaret M., Nathan, James, Wilson, Keith T., DeNardo, David, Zhang, Siyuan, Cook, Rebecca, Boothby, Mark, Chen, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455083/
https://www.ncbi.nlm.nih.gov/pubmed/32759497
http://dx.doi.org/10.1172/jci.insight.139237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455083/
https://www.ncbi.nlm.nih.gov/pubmed/32759497
http://dx.doi.org/10.1172/jci.insight.139237

Ejemplares similares