Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling

Mutations in PKD1 (encoding for polycystin-1 [PC1]) are found in 80%–85% of patients with autosomal dominant polycystic kidney disease (ADPKD). We tested the hypothesis that changes in actin dynamics result from PKD1 mutations through dysregulation of compartmentalized centrosomal RhoA signaling med...

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Detalles Bibliográficos
Autores principales: Streets, Andrew J., Prosseda, Philipp P., Ong, Albert C.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455122/
https://www.ncbi.nlm.nih.gov/pubmed/32663194
http://dx.doi.org/10.1172/jci.insight.135385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455122/
https://www.ncbi.nlm.nih.gov/pubmed/32663194
http://dx.doi.org/10.1172/jci.insight.135385

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