CD47 prevents the elimination of diseased fibroblasts in scleroderma

Scleroderma is a devastating fibrotic autoimmune disease. Current treatments are partly effective in preventing disease progression but do not remove fibrotic tissue. Here, we evaluated whether scleroderma fibroblasts take advantage of the “don’t-eat-me-signal” CD47 and whether blocking CD47 enables...

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Detalles Bibliográficos
Autores principales: Lerbs, Tristan, Cui, Lu, King, Megan E., Chai, Tim, Muscat, Claire, Chung, Lorinda, Brown, Ryanne, Rieger, Kerri, Shibata, Tyler, Wernig, Gerlinde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455137/
https://www.ncbi.nlm.nih.gov/pubmed/32814713
http://dx.doi.org/10.1172/jci.insight.140458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455137/
https://www.ncbi.nlm.nih.gov/pubmed/32814713
http://dx.doi.org/10.1172/jci.insight.140458

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