Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors

It is widely understood that CRISPR-Cas9 technology is revolutionary, with well-recognized issues including the potential for off-target edits and the attendant need for spatiotemporal control of editing. Here, we describe a far-red light (FRL)–activated split-Cas9 (FAST) system that can robustly in...

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Detalles Bibliográficos
Autores principales: Yu, Yuanhuan, Wu, Xin, Guan, Ningzi, Shao, Jiawei, Li, Huiying, Chen, Yuxuan, Ping, Yuan, Li, Dali, Ye, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455487/
https://www.ncbi.nlm.nih.gov/pubmed/32923591
http://dx.doi.org/10.1126/sciadv.abb1777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455487/
https://www.ncbi.nlm.nih.gov/pubmed/32923591
http://dx.doi.org/10.1126/sciadv.abb1777

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