Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4(+) T cells

Transgenic coexpression of a class I–restricted tumor antigen–specific T cell receptor (TCR) and CD8αβ (TCR8) redirects antigen specificity of CD4(+) T cells. Reinforcement of biophysical properties and early TCR signaling explain how redirected CD4(+) T cells recognize target cells, but the transcr...

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Detalles Bibliográficos
Autores principales: Rath, Jan A., Bajwa, Gagan, Carreres, Benoit, Hoyer, Elisabeth, Gruber, Isabelle, Martínez-Paniagua, Melisa A., Yu, Yi-Ru, Nouraee, Nazila, Sadeghi, Fatemeh, Wu, Mengfen, Wang, Tao, Hebeisen, Michael, Rufer, Nathalie, Varadarajan, Navin, Ho, Ping-Chih, Brenner, Malcolm K., Gfeller, David, Arber, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455496/
https://www.ncbi.nlm.nih.gov/pubmed/32923584
http://dx.doi.org/10.1126/sciadv.aaz7809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455496/
https://www.ncbi.nlm.nih.gov/pubmed/32923584
http://dx.doi.org/10.1126/sciadv.aaz7809

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