Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II

Reversible phosphorylation of Pol II and accessory factors helps order the transcription cycle. Here, we define two kinase-phosphatase switches that operate at different points in human transcription. Cdk9/cyclin T1 (P-TEFb) catalyzes inhibitory phosphorylation of PP1 and PP4 complexes that localize...

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Detalles Bibliográficos
Autores principales: Parua, Pabitra K., Kalan, Sampada, Benjamin, Bradley, Sansó, Miriam, Fisher, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455706/
https://www.ncbi.nlm.nih.gov/pubmed/32859893
http://dx.doi.org/10.1038/s41467-020-18173-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455706/
https://www.ncbi.nlm.nih.gov/pubmed/32859893
http://dx.doi.org/10.1038/s41467-020-18173-6

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