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Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
Reversible phosphorylation of Pol II and accessory factors helps order the transcription cycle. Here, we define two kinase-phosphatase switches that operate at different points in human transcription. Cdk9/cyclin T1 (P-TEFb) catalyzes inhibitory phosphorylation of PP1 and PP4 complexes that localize...
Autores principales: | Parua, Pabitra K., Kalan, Sampada, Benjamin, Bradley, Sansó, Miriam, Fisher, Robert P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455706/ https://www.ncbi.nlm.nih.gov/pubmed/32859893 http://dx.doi.org/10.1038/s41467-020-18173-6 |
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