Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation

Pancreatic β-cells are responsible for production and secretion of insulin in response to increasing blood glucose levels. Defects in β-cell function lead to hyperglycemia and diabetes mellitus. Here, we show that CNOT3, a CCR4–NOT deadenylase complex subunit, is dysregulated in islets in diabetic d...

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Detalles Bibliográficos
Autores principales: Mostafa, Dina, Yanagiya, Akiko, Georgiadou, Eleni, Wu, Yibo, Stylianides, Theodoros, Rutter, Guy A., Suzuki, Toru, Yamamoto, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455721/
https://www.ncbi.nlm.nih.gov/pubmed/32859966
http://dx.doi.org/10.1038/s42003-020-01201-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455721/
https://www.ncbi.nlm.nih.gov/pubmed/32859966
http://dx.doi.org/10.1038/s42003-020-01201-y

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